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Test rolapitant doses for CINV
September 30, 2013
By: Gil Roth
President, Pharma & Biopharma Outsourcing Association
Tesaro, Inc. has initiated an open label, dose-finding and escalation study to evaluate the pharmacokinetics, safety and tolerability of an intravenous (IV) formulation of rolapitant in healthy volunteers. Rolapitant is an investigational neurokinin-1 (NK-1) receptor antagonist in development for the prevention of chemotherapy-induced nausea and vomiting (CINV). Data from this Phase I study will be used to select the intravenous dose that will be advanced into a subsequent clinical study....
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